Textile-Based Structure to Treat Left Main Coronary Artery Disease



Team Members:

Nicholas Rinz

Tim Sasser

Liz Smith

Devjot Singh

Project Statement:

Coronary artery disease is a very common condition affecting more than 3 million Americans each year. A progressive narrowing of the coronary arteries from the buildup of plaque occurs over years and can restrict the flow of blood to the heart muscle resulting in a heart attack. One of the most common areas that this disease occurs is localized in the left main coronary artery (LMCA). In this space, the treatment of lesions and blockages at the bifurcation point (the branching of larger vessels into smaller vessels) from the LMCA to the Left Circumflex and the Left Anterior Descending coronary arteries is of interest. One of the challenges in this particular area of anatomy is the difficulty in successfully stenting (current treatment modality) due to the complexity of the geometry.

The objective of this project is to identify and create a textile-based structure/prosthesis that addresses the complex anatomy of the left main coronary artery.  The scope of this project includes:

  • Understanding the disease state, epidemiology and current state of medical devices used to treat LMCA disease and their shortcomings
  • Developing a computational model of the left main with specific emphasis at the bifurcation point
  • Develop a textile-based product that utilizes bifurcating braid or weaving techniques from the relevant implantable biomaterials

Fabricate several working models of said textile structure and conduct ex-vivo testing to determine functionality of each prototype iteration