{"id":41627,"date":"2023-02-03T15:38:20","date_gmt":"2023-02-03T20:38:20","guid":{"rendered":"https:\/\/textiles.ncsu.edu\/?p=41627"},"modified":"2024-11-24T13:40:57","modified_gmt":"2024-11-24T18:40:57","slug":"textiles-researchers-prepare-stem-cells-to-become-organ-tissue","status":"publish","type":"post","link":"https:\/\/textiles.ncsu.edu\/news\/2023\/02\/textiles-researchers-prepare-stem-cells-to-become-organ-tissue\/","title":{"rendered":"Textiles Researchers Prepare Stem Cells to Become Organ Tissue"},"content":{"rendered":"\n<p>Nearly 3,000 people died waiting for an organ transplant in 2022, according to the Organ Procurement and Transplantation Network, and more than 100,000 people remain on the waitlist. Envisioning a future without the need for donor organs, an NC&#160;State researcher is laying the foundation to grow stem cells into replacement organ tissue.<\/p>\n\n\n<p><a href=\"https:\/\/textiles.ncsu.edu\/people\/jmgluck\/\">Jessica M. Gluck<\/a>, an assistant professor of <a href=\"https:\/\/textiles.ncsu.edu\/tecs\/\">textile engineering, chemistry and science<\/a> in the <a href=\"https:\/\/textiles.ncsu.edu\/\">Wilson College of Textiles<\/a>, studies microenvironments in the human body. These microenvironments foster cell growth and activity, and they have different physical and mechanical properties depending on where in the body they are.&nbsp;<\/p>\n\n\n<p><a href=\"https:\/\/sites.textiles.ncsu.edu\/glucklab\/\">Gluck\u2019s lab<\/a> experiments with nanofibrous materials to create scaffolding that can transfer stem cells into the body. Cells taken from an individual can be essentially reprogrammed into embryonic-like stem cells. The stem cells are pluripotent, so they can regenerate into any cell in the body. Gluck and her team alter the nanofibrous scaffolding\u2019s properties to mimic certain microenvironments, which in turn encourages the stem cells to become a specific type of cell or grow into a specific tissue.&nbsp;<\/p>\n\n\n<aside class=\"wp-block-ncst-highlight with-image\"><h2 class=\"highlight__label\">Related<\/h2><a href=\"https:\/\/textiles.ncsu.edu\/news\/2020\/05\/heart-maker-meet-new-tecs-assistant-professor-jessica-gluck\/\" class=\"highlight__link\" data-ua-cat=\"Highlight Block\" data-ua-action=\"Story Click\" data-ua-label=\"https:\/\/textiles.ncsu.edu\/news\/2020\/05\/heart-maker-meet-new-tecs-assistant-professor-jessica-gluck\/\"><div class=\"highlight__image-container\"><div class=\"highlight__image-background\"><img decoding=\"async\" class=\"highlight__image wp-image-542321\" src=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/assistant-professor-jessica-gluck.jpeg\" \/><\/div><\/div><div class=\"highlight__text-container\"><h3 class=\"highlight__heading\">Heart Maker: Meet TECS Assistant Professor Jessica Gluck<\/h3><p class=\"highlight__teaser\">An NC&#160;State alumna, Gluck brings a passion for biomedical engineering to the textiles lab. <\/p><p class=\"highlight__cta\"><span>Learn more about <\/span><span class=\"nowrap\"><span>Gluck&nbsp;<\/span><span class=\"arrow-indicator\"> <svg class=\"wolficon\" role=\"img\" aria-hidden=\"true\"><use xlink:href=\"#wolficon-arrow-right-bold\" \/><\/svg> <\/span><\/span><\/p><\/div><\/a><\/aside>\n\n\n<p>The basic science research occurring in Gluck\u2019s lab will bolster future applied research focused on repairing and growing organs: Understanding the nuances of cell development will help researchers learn how to prevent disease and to create new tissue.<\/p>\n\n\n<p>\u201cWe wouldn\u2019t need donor organs or donor tissue. People wouldn\u2019t need to worry about their bodies rejecting transplanted organs,\u201d Gluck said. \u201cWe\u2019re still a long way from that reality, but I think in the next 20 years, we\u2019ll start to see this process becoming more feasible in personalized medicine.\u201d<\/p>\n\n\n<blockquote class=\"wp-block-ncst-pullquote has-indigo-400-text-color has-quotes\"><div class=\"pullquote-container\"><p class=\"pullquote-content\">On the surface, textiles sound like socks and towels. When you\u2019re looking at the industry as a whole, you\u2019re looking at things made out of polymers, which is pretty much everything.<\/p><\/div><\/blockquote>\n\n\n<p>Gluck and her team experiment in creating scaffolding that specifically mimics microenvironments in the heart and the cornea. The research involves a mix of textiles, biomedical engineering, medicine and mechanical engineering. Gluck has worked alongside the <a href=\"https:\/\/ece.ncsu.edu\/\">Department of Electrical and Computer Engineering<\/a> and the <a href=\"https:\/\/bme.unc.edu\/\">Joint Department of Biomedical Engineering<\/a> to study electrical currents in cardiac cells. Gluck is also part of the <a href=\"https:\/\/cvm.ncsu.edu\/comparative-medicine-institute\/\">Comparative Medicine Institute<\/a>, which fosters interdisciplinary research and scientific discovery to improve human and animal health. A multidisciplinary approach is vital to the lab.&nbsp;<\/p>\n\n\n<p>Suh Hee Cook, a Ph.D. candidate in the <a href=\"https:\/\/textiles.ncsu.edu\/academics\/graduate\/fiber-and-polymer-science\/\">Fiber and Polymer Science program<\/a>, had studied biomedical engineering before joining the Wilson College of Textiles. They planned on earning a Ph.D. in biomedical engineering before they learned Gluck was researching cardiac tissue. Now, they study how pluripotent stem cells can become cardiac myocytes.<\/p>\n\n\n<p>\u201cWe\u2019ve gotten to the point where the stem cells beat like cardiac myocytes, but they don\u2019t beat as strongly or as synchronized as an actual myocyte,\u201d Cook said. \u201cWe\u2019re interested in conductive materials, since a heartbeat is an electrical thing. As we\u2019re fabricating the material, we want to see how cells respond to it and if they\u2019re beating better.\u201d<\/p>\n\n\n<p>Gluck\u2019s team experiments with the nanofibrous scaffolding\u2019s mechanical and physical properties, changing things like protein levels, elasticity and conductivity, to create a stable microenvironment that\u2019s similar to those found in certain organs. Nasif Mahmood, also a Ph.D. candidate in the Fiber and Polymer Science program, is studying ocular surface repair and creating scaffolding similar to corneal tissue. The material must be transparent so it doesn\u2019t block vision, and it must support cell growth.<\/p>\n\n\n<p>Mahmood has studied textiles and consumer science. He didn\u2019t originally plan on joining the biomedical field, but he was fascinated by Gluck\u2019s work with pluripotent stem cells.<\/p>\n\n\n<p>\u201cI never would have imagined I\u2019d be here doing this kind of research,\u201d Mahmood said. \u201cI never enjoyed biology that much. My background is in textiles. As a textiles college, there are a lot of fascinating things in our labs.\u201d<\/p>\n\n\n<section class=\"wp-block-ncst-image-grid\">\n<section class=\"wp-block-ncst-image-column\">\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/Suh_Hee_square.jpg\"><img decoding=\"async\" src=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/Suh_Hee_square.jpg\" alt=\"\" class=\"wp-image-542335\" \/><\/a><figcaption>Suh Hee Cook<\/figcaption><\/figure>\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/Nasif_square.jpg\"><img decoding=\"async\" src=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/Nasif_square.jpg\" alt=\"\" class=\"wp-image-542336\" \/><\/a><figcaption>Nasif Mahmood<\/figcaption><\/figure>\n<\/section>\n<\/section>\n\n\n\n<p>\u201cOn the surface, textiles sound like socks and towels,\u201d Gluck said. \u201cWhen you\u2019re looking at the industry as a whole, you\u2019re looking at things made out of polymers, which is pretty much everything. You\u2019re looking at dyeing textiles. The industry is insanely multidisciplinary.\u201d<\/p>\n\n\n<p>This work is just the beginning of life-saving research.<\/p>\n\n\n<p>\u201cWhen I take a step back, I think, \u2018This is kind of insane, watching stem cells turn into heart tissue and beat in a dish,\u2019\u201d Cook said. \u201cThe process of scientific discovery is very rewarding to me \u2014 to uncover a piece of knowledge and share it with scientists. We\u2019re doing this small part of pushing our field forward, and we\u2019re contributing this piece of knowledge that could revolutionize the medical field and save a lot of people\u2019s lives.\u201d<\/p>\n<p><em>This post was <a href=\"https:\/\/news.ncsu.edu\/2023\/02\/textiles-stem-cells-into-organ-tissue\/\">originally published<\/a> in NC&#160;State News.<\/em><\/p>","protected":false,"raw":"<!-- wp:paragraph -->\n<p>Nearly 3,000 people died waiting for an organ transplant in 2022, according to the Organ Procurement and Transplantation Network, and more than 100,000 people remain on the waitlist. Envisioning a future without the need for donor organs, an NC State researcher is laying the foundation to grow stem cells into replacement organ tissue.<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/textiles.ncsu.edu\/people\/jmgluck\/\">Jessica M. Gluck<\/a>, an assistant professor of <a href=\"https:\/\/textiles.ncsu.edu\/tecs\/\">textile engineering, chemistry and science<\/a> in the <a href=\"https:\/\/textiles.ncsu.edu\/\">Wilson College of Textiles<\/a>, studies microenvironments in the human body. These microenvironments foster cell growth and activity, and they have different physical and mechanical properties depending on where in the body they are.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p><a href=\"https:\/\/sites.textiles.ncsu.edu\/glucklab\/\">Gluck\u2019s lab<\/a> experiments with nanofibrous materials to create scaffolding that can transfer stem cells into the body. Cells taken from an individual can be essentially reprogrammed into embryonic-like stem cells. The stem cells are pluripotent, so they can regenerate into any cell in the body. Gluck and her team alter the nanofibrous scaffolding\u2019s properties to mimic certain microenvironments, which in turn encourages the stem cells to become a specific type of cell or grow into a specific tissue.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:ncst\/highlight {\"teaser\":\"An NC State alumna, Gluck brings a passion for biomedical engineering to the textiles lab. \",\"callToAction\":\"Learn more about Gluck\",\"imageID\":542321} -->\n<aside class=\"wp-block-ncst-highlight with-image\"><h2 class=\"highlight__label\">Related<\/h2><a href=\"https:\/\/textiles.ncsu.edu\/news\/2020\/05\/heart-maker-meet-new-tecs-assistant-professor-jessica-gluck\/\" class=\"highlight__link\" data-ua-cat=\"Highlight Block\" data-ua-action=\"Story Click\" data-ua-label=\"https:\/\/textiles.ncsu.edu\/news\/2020\/05\/heart-maker-meet-new-tecs-assistant-professor-jessica-gluck\/\"><div class=\"highlight__image-container\"><div class=\"highlight__image-background\"><img class=\"highlight__image wp-image-542321\" src=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/assistant-professor-jessica-gluck.jpeg\" \/><\/div><\/div><div class=\"highlight__text-container\"><h3 class=\"highlight__heading\">Heart Maker: Meet TECS Assistant Professor Jessica Gluck<\/h3><p class=\"highlight__teaser\">An NC State alumna, Gluck brings a passion for biomedical engineering to the textiles lab. <\/p><p class=\"highlight__cta\"><span>Learn more about <\/span><span class=\"nowrap\"><span>Gluck&nbsp;<\/span><span class=\"arrow-indicator\"> <svg class=\"wolficon\" role=\"img\" aria-hidden=\"true\"><use xlink:href=\"#wolficon-arrow-right-bold\" \/><\/svg> <\/span><\/span><\/p><\/div><\/a><\/aside>\n<!-- \/wp:ncst\/highlight -->\n<!-- wp:paragraph -->\n<p>The basic science research occurring in Gluck\u2019s lab will bolster future applied research focused on repairing and growing organs: Understanding the nuances of cell development will help researchers learn how to prevent disease and to create new tissue.<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p>\u201cWe wouldn\u2019t need donor organs or donor tissue. People wouldn\u2019t need to worry about their bodies rejecting transplanted organs,\u201d Gluck said. \u201cWe\u2019re still a long way from that reality, but I think in the next 20 years, we\u2019ll start to see this process becoming more feasible in personalized medicine.\u201d<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:ncst\/pullquote {\"value\":\"\\u0022On the surface, textiles sound like socks and towels. When you\u2019re looking at the industry as a whole, you\u2019re looking at things made out of polymers, which is pretty much everything.\\u0022\",\"textColor\":\"indigo_400\"} -->\n<blockquote class=\"wp-block-ncst-pullquote has-indigo-400-text-color has-quotes\"><div class=\"pullquote-container\"><p class=\"pullquote-content\">On the surface, textiles sound like socks and towels. When you\u2019re looking at the industry as a whole, you\u2019re looking at things made out of polymers, which is pretty much everything.<\/p><\/div><\/blockquote>\n<!-- \/wp:ncst\/pullquote -->\n<!-- wp:paragraph -->\n<p>Gluck and her team experiment in creating scaffolding that specifically mimics microenvironments in the heart and the cornea. The research involves a mix of textiles, biomedical engineering, medicine and mechanical engineering. Gluck has worked alongside the <a href=\"https:\/\/ece.ncsu.edu\/\">Department of Electrical and Computer Engineering<\/a> and the <a href=\"https:\/\/bme.unc.edu\/\">Joint Department of Biomedical Engineering<\/a> to study electrical currents in cardiac cells. Gluck is also part of the <a href=\"https:\/\/cvm.ncsu.edu\/comparative-medicine-institute\/\">Comparative Medicine Institute<\/a>, which fosters interdisciplinary research and scientific discovery to improve human and animal health. A multidisciplinary approach is vital to the lab.&nbsp;<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p>Suh Hee Cook, a Ph.D. candidate in the <a href=\"https:\/\/textiles.ncsu.edu\/academics\/graduate\/fiber-and-polymer-science\/\">Fiber and Polymer Science program<\/a>, had studied biomedical engineering before joining the Wilson College of Textiles. They planned on earning a Ph.D. in biomedical engineering before they learned Gluck was researching cardiac tissue. Now, they study how pluripotent stem cells can become cardiac myocytes.<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p>\u201cWe\u2019ve gotten to the point where the stem cells beat like cardiac myocytes, but they don\u2019t beat as strongly or as synchronized as an actual myocyte,\u201d Cook said. \u201cWe\u2019re interested in conductive materials, since a heartbeat is an electrical thing. As we\u2019re fabricating the material, we want to see how cells respond to it and if they\u2019re beating better.\u201d<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p>Gluck\u2019s team experiments with the nanofibrous scaffolding\u2019s mechanical and physical properties, changing things like protein levels, elasticity and conductivity, to create a stable microenvironment that\u2019s similar to those found in certain organs. Nasif Mahmood, also a Ph.D. candidate in the Fiber and Polymer Science program, is studying ocular surface repair and creating scaffolding similar to corneal tissue. The material must be transparent so it doesn\u2019t block vision, and it must support cell growth.<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p>Mahmood has studied textiles and consumer science. He didn\u2019t originally plan on joining the biomedical field, but he was fascinated by Gluck\u2019s work with pluripotent stem cells.<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p>\u201cI never would have imagined I\u2019d be here doing this kind of research,\u201d Mahmood said. \u201cI never enjoyed biology that much. My background is in textiles. As a textiles college, there are a lot of fascinating things in our labs.\u201d<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:ncst\/image-grid -->\n<section class=\"wp-block-ncst-image-grid\"><!-- wp:ncst\/image-column -->\n<section class=\"wp-block-ncst-image-column\"><!-- wp:image {\"id\":542335,\"sizeSlug\":\"full\",\"linkDestination\":\"media\"} -->\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/Suh_Hee_square.jpg\"><img src=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/Suh_Hee_square.jpg\" alt=\"\" class=\"wp-image-542335\" \/><\/a><figcaption>Suh Hee Cook<\/figcaption><\/figure>\n<!-- \/wp:image -->\n<!-- wp:image {\"id\":542336,\"sizeSlug\":\"full\",\"linkDestination\":\"media\"} -->\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/Nasif_square.jpg\"><img src=\"https:\/\/news.ncsu.edu\/wp-content\/uploads\/2023\/02\/Nasif_square.jpg\" alt=\"\" class=\"wp-image-542336\" \/><\/a><figcaption>Nasif Mahmood<\/figcaption><\/figure>\n<!-- \/wp:image --><\/section>\n<!-- \/wp:ncst\/image-column --><\/section>\n<!-- \/wp:ncst\/image-grid -->\n\n<!-- wp:paragraph -->\n<p>\u201cOn the surface, textiles sound like socks and towels,\u201d Gluck said. \u201cWhen you\u2019re looking at the industry as a whole, you\u2019re looking at things made out of polymers, which is pretty much everything. You\u2019re looking at dyeing textiles. The industry is insanely multidisciplinary.\u201d<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p>This work is just the beginning of life-saving research.<\/p>\n<!-- \/wp:paragraph -->\n<!-- wp:paragraph -->\n<p>\u201cWhen I take a step back, I think, \u2018This is kind of insane, watching stem cells turn into heart tissue and beat in a dish,\u2019\u201d Cook said. \u201cThe process of scientific discovery is very rewarding to me \u2014 to uncover a piece of knowledge and share it with scientists. We\u2019re doing this small part of pushing our field forward, and we\u2019re contributing this piece of knowledge that could revolutionize the medical field and save a lot of people\u2019s lives.\u201d<\/p>\n<!-- \/wp:paragraph -->"},"excerpt":{"rendered":"<p>An NC State researcher is laying the foundation to grow stem cells into replacement organ tissue, which would eliminate the need for donor organs.<\/p>\n","protected":false},"author":13,"featured_media":41632,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"source":"ncstate_wire","ncst_custom_author":"","ncst_show_custom_author":false,"ncst_dynamicHeaderBlockName":"ncst\/default-post-header","ncst_dynamicHeaderData":"{\"showAuthor\":true,\"showDate\":true,\"showFeaturedVideo\":false,\"caption\":\"A microscopic image of fibroblast cells on nylon.\",\"displayCategoryID\":742}","ncst_content_audit_freq":"","ncst_content_audit_date":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[742,512,502,479],"tags":[1143,2327,1055,504,1382],"class_list":["post-41627","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newswire","category-research-and-innovation","category-student-success","category-tecs","tag-department-of-textile-engineering-chemistry-and-science","tag-faculty-research","tag-ph-d-fiber-and-polymer-science","tag-research","tag-wilson-college-of-textiles"],"displayCategory":{"term_id":742,"name":"Newswire","slug":"newswire","term_group":0,"term_taxonomy_id":742,"taxonomy":"category","description":"","parent":0,"count":482,"filter":"raw"},"acf":[],"yoast_head":"<title>Textiles Researchers Prepare Stem Cells to Become Organ Tissue - 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