Nelson Vinueza Benitez
Bio
Research in the Vinueza group centers around three aspects of mass spectrometry (MS): fundamentals, instrumentation and applications. Fundamental studies aimed to enhance the analytical capabilities of mass spectrometry focus on the characterization of dyes from the recent donated Max Weaver dye library, with around 100,000 dyes. Instrumentation development includes a wide range of projects in tandem mass spectrometry (MS/MS), chromatography and microfluidics. We are currently utilizing microfluidics to extract dyes from fibers in combination with a quadrupole-time-of-flight for a faster characterization. Applications of MS techniques developed in our group include studies in biofuels and forensic analysis. Current projects include characterization of bio-oil from lignocellulose biomass, sequencing of oligosaccharides and fast analysis of chemicals of forensic interest, such as dyes, inks, fibers, polymers and drugs. These applications involve direct collaboration with colleagues in other departments on campus and around the world. Mass spectrometry, chromatography, FT-Raman, FT-IR, organic synthesis and gas-phase ion chemistry are central tools for the lab.Research
Teaching
Education
Post-doctoral fellow C3Bio, DOE EFRC (Energy Frontiers Research Center) Research Focus: Develop mass spectrometry methods for the analysis of lignin and cellulose degradation products as well as bio-oil Purdue University 2012
Ph.D. Physical Organic Chemistry Purdue University 2010
Dissertation Reactivity Studies of Charged σ,σ,σ-Triradicals Using the Distonic Ion Approach and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
B.S. Chemical Engineering Universidad San Francisco de Quito, Quito-Ecuado 2003
B.S. Industrial Chemistry Universidad San Francisco de Quito, Quito-Ecuado 2001
Area(s) of Expertise
Analytical Chemistry
Color Science
Dyeing and Finishing
Forensics
Sustainability
Textile Chemistry
Publications
- Expansion of a chemically diverse fluoroprobe library to further utilize protein-adaptive differential scanning fluorimetry (paDSF) , BIOPHYSICAL JOURNAL (2025)
- High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs , NATURE CHEMISTRY (2025)
- Impaired cell viability and mitochondrial respiration by disperse textile dyes , FRONTIERS IN ALLERGY (2025)
- Solvatochromic BODIPYs with Polarity-Independent Absorption for Functional Super-resolution Imaging of Live Cell Membranes , Chemical & Biomedical Imaging (2025)
- The importance of the YG1041 Salmonella strain in the mutagenicity characterization of azo dyes , FOOD AND CHEMICAL TOXICOLOGY (2025)
- Exploration of the binding determinants of protein phosphatase 5 (PP5) reveals a chaperone-independent activation mechanism , JOURNAL OF BIOLOGICAL CHEMISTRY (2024)
- Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes , NATURE BIOTECHNOLOGY (2024)
- The Role of Textile Dyes in the Immune System Dysregulation , JOURNAL OF IMMUNOLOGY (2024)
- Quantification of docusate antimicrobial finishing after simulated landfill degradation via tandem mass spectrometry and QuEChERS extraction , ANALYTICAL METHODS (2022)
- Synthetic dyes: A mass spectrometry approach and applications , MASS SPECTROMETRY REVIEWS (2022)